Issue No. 20Week ending Sunday, May 17, 2026624 episodes · 2751 articles
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I put 80% of my money in the S&P after a billionaire investor told me not to

With Sam Parr, Shaan Puri · Sunday, May 17, 2026

Sam and Shaan delve into a study suggesting a significant genetic component to investing behavior, exploring how self-awareness and tailored strategies can mitigate biases. They then pivot to future business trends, discussing the need for "aesthetic data centers" to counter public backlash, the revolutionary concept of AI as a "company brain" where humans feed and execute decisions, the changing landscape of entrepreneurship across tech waves from social media to hard tech, and the radical applications of AI in personalized medicine, including a story of an AI managing a person's hydration and navigating their self-driving car.

Key takeaways

  • AI’s rapid growth demands huge data centers and power grids, but public sentiment often rejects this necessary infrastructure, leading to “not in my backyard” (NIMBY) resistance. Read more →
  • Shaan Puri asserts that AI is rapidly evolving beyond a tool or assistant to become the primary "company brain," making core decisions with humans acting as contextual inputs and executors. Read more →
  • Autonomous AI agents are closing the loop on health: Forget dashboards; intelligent AI like Claude is now analyzing genetic data, blood tests, and wearables to diagnose issues, then acting on them. One user had Claude reroute his Tesla to a store for rehydration supplements after detecting chronic dehydration. Read more →
  • Peter Thiel's axiom holds true: the next big thing won't look like the last, meaning yesterday's successful founder archetypes and strategies are obsolete for today's opportunities. Read more →
  • A striking Swedish twin study suggests 45% of our saving and investing behaviors are genetic, influenced by biases like excess turnover and home bias. It's not just about education; our wiring plays a huge role. Read more →

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