Issue No. 43Week ending Sunday, October 25, 2026620 episodes · 2733 articles
The Throughline ↓
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The Throughline · Issue 42

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Issue No. 43 · Week ending October 25, 2026AI · Tech · Business · Science · Culture · Private Equity · Shows · Archive
11 episodes this week · 49 articles across 11 shows
Shows we cover
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★ The Throughline · Issue 42

Software has a marginal cost again

Plus, why AI models fail at UI design, the illusion of AI drug discovery, and the death of the app store.

01AI models cannot grasp human user interfaces
02Software now carries a marginal cost
03AI drug discovery models cannot bypass physical biology
Read the full Throughline · 6 min
6 min read · 15 podcasts · 148 articles · Sunday, October 18, 2026
★ Longitudinal Report · Quarter

The State Of: Q2 2026

What 15 top podcasts converged on and fought about in Q2 2026.

Read the report · 11 min
11 min read · 719 episode write-ups

The rest of this week.

BusinessAcquired

The Business of Seinfeld - Full Episode (Audio)

Ben Gilbert and David Rosenthal explore the business and economic history of Seinfeld, detailing how regulatory quirks, aligned incentives, and obsessive craft…

AIHow I AI

Claude Code for creators: AI editing is here

Tech veteran and creator Brooke Lacey demonstrates how she uses Claude Code alongside terminal tools like FFmpeg and Whisper to automate short-form video editi…

ScienceHidden Brain

Do You Have Trouble Sleeping?

Sleep researcher Chris Barnes explains how chronic sleep deprivation impairs cognitive decision-making, fuels unethical conduct, and contributes to industrial…

From last week's issue.

Issue No. 42 · Week ending Sunday, October 18, 2026