How I use ChatGPT to run my fashion business
Claire Vo interviews Yana Welander about her AI-native fashion startup, Yana Banana. Welander details how she leverages AI throughout the entire business proce…
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AI podcast summaries.
Building with AI, investing in AI, and the people shaping it. Lenny's Podcast, How I AI, No Priors, Latent Space. Covering How I AI, Latent Space, Lenny's Podcast, No Priors.
73 episodesin ai
323 articlescovered
323 articlescovered
How Nuclear Will Unlock Energy Abundance with Valar Atomics Founder Isaiah Taylor
Isaiah Taylor, CEO of Valor Atomics, discusses their approach to rapidly scale nuclear fission through hardware iteration and manufacturing, contrasting it wit…
Exo: Harnesses should see their own code and logs — Alex Krentsel, UC Berekeley / Google Research
This episode features Alex Krentsel discussing Exo, a novel AI agent designed for fully recursive self-improvement. He explains how Exo's unique three-layer ha…
OpenAI’s Head of Design: This is the best time in history to be a designer | Ian Silber
Lenny Rachitsky discusses his survey finding designers as the unhappiest in tech, a sentiment Ian Silber attributes to uncertainty surrounding AI's impact on t…
🔬Biology Is Turning Into Software — Matt McPartlon and Neil Patil, Chai Discovery
This episode features Matt McPartlon and Neil Patil from Chai Discovery, a protein design startup, discussing their AI models (Chai 1, 2, and 3) for protein an…
The playbook for building high talent density teams | Adam Ward, Head of Talent at Cursor
Lenny Rachitsky and Adam Ward discuss how to build elite, high talent density teams by moving beyond the traditional 'funnel of doom' recruiting. They explore…
Chasing Trillion-Dollar Companies, Founder Ambition, Token Budgets, & Regulatory Capture
Sarah Guo and Elad Gil discuss the rapid rise of trillion-dollar AI companies, questioning the sustainability of such velocity and whether founders are becomin…
How this OpenAI engineer uses Codex + ChatGPT Work to automate everything
Claire Vo, joined by OpenAI's Nick Bowman, explores advanced use cases of Codex and ChatGPT Work, including voice-activated task delegation, multi-threaded AI…
Next 100x in AI: Inference, Networking, & Self-Optimizing Models — Philip Kiely & Ali Taha, Baseten
This episode of Latent Space features Philip Kiely and Ali Taha from Baseten, discussing advanced inference engineering for AI models. They delve into strategi…
OpenAI’s Vision for the AI Super App — Akshay Nathan, OpenAI
Akshay Nathan from OpenAI discusses the launch of ChatGPT Work, positioning it as an AI super app that merges ChatGPT and Codex capabilities to democratize the…
This CPO regrets that product management exists | Tom Verrilli (CPO of Whatnot)
In this episode, Tom Verrilli, CPO of Whatnot, shares his provocative stance that product management's widespread existence is regrettable, advocating for empo…
Building an Autonomous Enterprise for Real-World Services with Netic Founder Melisa Tokmak
Melisa Tokmak, founder and CEO of Netic, discusses how her company builds AI to autonomously run real-world service businesses like HVAC and pet care. She expl…
The AI Frontier: from open weights to open research — Eiso Kant, Poolside AI
Eiso Kant, CEO of Poolside AI, discusses his company's mission to foster an open and competitive AI landscape, moving away from an oligopoly of intelligence. H…
I hate Opus 5. It’s the best model, anyway.
Claire Vo opens up about her exhaustion with the rapid release of new AI models, proposing a future shift in focus from raw intelligence to factors like speed,…
Building an Autonomous Delivery Experience with DoorDash Co-Founders Andy Fang and Stanley Tang
DoorDash co-founders Andy Fang and Stanley Tang discuss the company's ambitious foray into Agentic Commerce and autonomous delivery with their robot, DOT. They…
🔬Causal Models Need Causal Data - Xaira’s X-Cell model (Bo Wang & Ci Chu)
This episode delves into Zera Therapeutics' AI drug discovery platform, focusing on their X-Cell model. Guests Bo Wang and Ci Chu explain how X-Cell leverages…
How Anthropic builds products like Claude Code before the AI models are ready | Dianne Penn
In this episode, Dianne Penn, head of product for Anthropic's AI research and labs teams, discusses Anthropic's journey from underdog to a leading AI company.…
The AI Memory Problem: Why Long Context Isn’t Enough — Dan Biderman, Engram Co-founder & CEO
During a cooking session, Engram co-founder and CEO Dan Biderman discusses his entrepreneurial journey from Israeli Naval Special Operations to leading an AI s…
🔬 RL with Verifiable Rewards, but the Verifier is a Lab — Lila Sciences
This episode explores Lila Sciences' ambitious thesis of creating AI Science Factories, transforming labs into data centers that generate internet-scale, exper…
Why Netflix is betting on systems thinkers—not specialists—in the AI era | Elizabeth Stone (CPTO)
Lenny Rachitsky and Elizabeth Stone, CPTO of Netflix, discuss the profound impact of AI on technology roles, organizational culture, and the future of entertai…
Local AI models explained: How to run a fleet of Mac Studios and GPUs at home
In this episode, Claire Vo and Alex Finn explore the practicalities of running local AI models at home, discussing the necessary hardware, setup processes, and…
How I run autonomous coding agents from my phone with OpenAI Symphony + Linear
Claire Vo and Alessio Finelli discuss how Alessio uses OpenAI's Symphony and Linear to manage autonomous coding agents, streamlining software development tasks…
The 100,000 Sandbox Problem — Akshat Bubna, Modal CTO
Akshat Bubna, CTO of Modal, discusses the company's evolution from a developer experience platform to one optimized for agent experience and specialized AI wor…
Podcast Crossover: AIE, AGI, frontier lab strategy with @matthew_berman and @swyxtv
In this crossover episode, Swyx, the founder of the AI Engineering Conference (AIE), discusses the origins and challenges of building the event. He delves into…
Why AI Agents Don't Actually Understand You — Danielle Perszyk, Amazon AGI Lab
Danielle Perszyk from Amazon AGI Lab discusses her vision for AI, emphasizing human collective intelligence and building agents that genuinely understand user…
Travel Through the Lens of AI with with Booking.com CEO Glenn Fogel
In this episode, Glenn Fogel, CEO of Booking Holdings, discusses the company's journey from Priceline to a global travel giant and its strategic approach to th…
Why the tech workforce is quietly splitting in two | Annual AI sentiment survey (Noam Segal)
This episode delves into the findings of the second annual tech worker sentiment survey conducted by Lenny Rachitsky and Noam Segal, revealing a deeply bifurca…
🔬 "The Most Innovative Diffusion Research Is Happening in Drug Discovery, Not Image Generation"
This episode explores how Genesis Molecular AI is leveraging advanced AI, particularly diffusion models, to revolutionize drug discovery by achieving unprecede…
How Nuclear Will Unlock Energy Abundance with Valar Atomics Founder Isaiah Taylor
This episode features Sarah Guo interviewing Isaiah Taylor, founder and CEO of Valor Atomics, about their work in developing scalable nuclear reactors. They di…
Cooking with OpenAI’s Research Chief: AGI, o1, Evals, and Scaling Laws — Mark Chen
OpenAI's Chief Research Officer, Mark Chen, joins Alessio Fanelli for a cooking session while discussing OpenAI's core research strategies. Topics include the…
Why Traditional Benchmarks Fail Modern AI Models with OpenAI Research Scientist Noam Brown
This episode features OpenAI research scientist Noam Brown discussing the shortcomings of current AI model evaluation benchmarks, particularly their failure to…
The Agent Cloud: Databricks’ Bet on the Future of AI — Matei Zaharia and Reynold Xin
This episode features Databricks co-founders Matei Zaharia and Reynold Xin discussing their latest innovations, including the Omnigents platform for agent deve…
AI Security After Codex and Claude Code — Zico Kolter & Matt Fredrikson, Gray Swan
This episode explores the evolving landscape of AI security with Gray Swan founders Zico Kolter and Matt Fredrikson. They discuss how AI systems introduce new…
OpenAI Codex lead on the new shape of product work | Andrew Ambrosino
This episode features Lenny Rachitsky and Andrew Ambrosino, product and engineering lead for the OpenAI Codex app. They discuss how AI, particularly Codex, is…
Loop engineering for beginners
This episode explores the concept of AI agent loops, contrasting them with traditional prompting and explaining how agents can be designed to prompt themselves…
🔬 The Limits of AI in Science - Why We Need Self-Driving Labs — Joseph Krause, Radical AI
Joseph Krause, CEO of Radical AI, discusses the inherent challenges of applying AI to material science compared to biology, emphasizing the necessity of experi…
⚡️Every product of the future will be a living system — Ronak Malde, Trajectory.ai
Ronak Malde, co-founder of Trajectory.ai, discusses his journey from Windsurf to DeepMind and ultimately to building Trajectory.ai. The conversation centers on…
How this startup uses AI agents to eliminate bugs and optimize infrastructure
Claire Vo and Anker Goyel discuss how AI agents are transforming software engineering, particularly for complex infrastructure and database optimization. Goyel…
Building the most AI-pilled engineering team in the world | Fiona Fung (Anthropic)
Fiona Fung, leader of Claude Code and Co-work teams at Anthropic, discusses the profound transformation of software engineering due to AI. She shares insights…
Re-engineering the Semiconductor Supply Chain with Intel CEO Lip Bu Tan
Intel CEO Lip Bu Tan discusses his ambitious plan to revitalize Intel, focusing on cultural shifts, balance sheet strengthening through strategic partnerships…
Why AI Labs With Unlimited GPUs Still Fail — Anjney Midha, AMP
In this episode, Anjney Midha, CEO of Amp, discusses why many AI labs struggle despite abundant resources, attributing failures to a lack of culture and organi…
Biohub: The Future of Biology is Open-Source with Mark Zuckerberg, Priscilla Chan, and Alex Rives
Mark Zuckerberg, Priscilla Chan, and Alex Rives discuss Biohub's mission to accelerate scientific progress through open-source tools and frontier AI combined w…
The hidden pattern behind successful products | Mark Pincus (FarmVille, Words with Friends, & more)
Mark Pincus, founder of Zynga, shares his 'Proven, Better, New' framework for product development, advocating for copying proven elements, making small improve…
She built a Claude shopping assistant to stop buying cheap junk
Nicole Ruiz shares how she leverages AI, specifically Claude, to create a personalized shopping assistant that curates high-quality, long-lasting products, avo…
Scaling Past Informal AI - Carina Hong, Axiom Math
This episode features Carina Hong, CEO of Axiom Math, discussing her company's vision for formal verification as the foundation for superintelligence and AGI,…
⚡️Making DeepSeek v4 outperform Opus 4.7 with Taste — @AhmadAwais , CommandCode.ai
Ahmad Awais discusses Command Code's "Taste" system for personalizing AI coding agents through automatically learned developer preferences. He reveals a novel…
Tony Fadell: How to build real taste (and why AI makes it matter more)
Tony Fadell, co-creator of the iPod, iPhone, and Nest, discusses the principles of building great products, from ideation using "pain and new technology" to th…
When AI Agents Run Businesses — Lukas Petersson and Axel Backlund of Andon Labs
Lukas Petersson and Axel Backlund of Andon Labs discuss their work evaluating AI agents, from simulated vending machine businesses to real-world robot deployme…
GitHub’s Agent Era: 14x Commits, 200M Developers, Copilot’s Next Act — Kyle Daigle
This episode features Kyle Daigle, CEO of GitHub and CMO of Developer for Microsoft, discussing the transformative impact of AI on software development and Git…
Satya Nadella on AI: @NoPriorsPodcast x Latent Space Crossover Special at Microsoft Build 2026
In this crossover episode, Satya Nadella, CEO of Microsoft, discusses the company's AI strategy, emphasizing an ecosystem approach for custom intelligence rath…
The Rise of the Full-Stack Builder and Hyper-Leveraged Generalist with Microsoft CEO Satya Nadella
Microsoft CEO Satya Nadella discusses the company's AI strategy, focusing on an ecosystem play where companies can build their own AI using specialized 'harnes…
🔬 The Bitter Lesson is Coming for Proteins - Alex Rives, BioHub
This episode features Alex Rives from Biohub discussing the application of the 'bitter lesson' (scaling laws and empirical evidence) to protein biology through…
Building an AI Guardian for Enterprise with Onyx Security CEO Maxim Bar Kogan
This episode features Sarah Guo interviewing Maxim Bar Kogan, CEO of Onyx Security, about the escalating security risks of autonomous AI agents in enterprise.…
Devin’s 80% Moment: Background Agents, 7x PRs, & End of Hand-Held Coding — Walden Yan & Cole Murray
This episode delves into the rapid evolution of AI coding agents, highlighted by Devin's increasing autonomy and efficiency. Guests Walden Yan and Cole Murray…
A rational conversation on where AI is actually going | Benedict Evans
Benedict Evans, a long-time tech analyst, shares his nuanced perspective on AI, comparing its impact to previous platform shifts like the internet and mobile.…
⚡️ Google's Open AI Strategy — Omar Sanseviero, Google DeepMind
Omar Sanseviero from Google DeepMind discusses the release and capabilities of Gemma 4, including its novel E2B architecture for on-device inference, its multi…
Amex Global Business Travel: The World’s First AI Take Private with Long Lake CEO Alexander Taubman
Long Lake CEO Alexander Taubman discusses his firm's unique AI-driven acquisition strategy, exemplified by the $6.3 billion take-private of American Express Gl…
Pax Silica: Inside the Trump Administration’s Tech Strategy with Jacob Helberg
Jacob Helberg, Under Secretary of State for Economic Affairs, discusses the Trump administration's "Pax Silica" initiative, a multi-nation coalition aimed at s…
Inside Abridge: The AI Listening to 100 Million Doctor Visits — Abridge's Janie Lee & Chai Asawa
This episode features a conversation with Janie Lee and Chai Asawa from Abridge, an AI company revolutionizing healthcare documentation and clinical intelligen…
Why we’re at the beginning of the AI hardware boom | Caitlin Kalinowski (ex–OpenAI, Meta, Apple)
This episode features a deep dive with Caitlin Kalinowski, an accomplished hardware leader, discussing the burgeoning AI hardware boom. The conversation explor…
Spec-driven development: the AI engineering workflow at Notion | Ryan Nystrom
Claire Vo and Ryan Nystrom, an engineering manager at Notion, discuss how AI has revolutionized their engineering workflows. They cover an AI agent that automa…
The internal AI tool that's transforming how Stripe designs products | Owen Williams
Claire Vo interviews Owen Williams, a design manager at Stripe, about "Protodash," an internal AI-powered prototyping tool he built. They discuss how Protodash…
🔬How GPT‑5 derived new results in theoretical physics and quantum gravity — Alex Lupsasca, OpenAI
Alex Lupsasca from OpenAI discusses how GPT models have achieved superhuman capabilities in theoretical physics, detailing two groundbreaking papers on gluon a…
How to build a company that withstands any era | Eric Ries, Lean Startup author
Lenny Rachitsky and Eric Ries discuss the ideas from Ries's new book, "Incorruptible," which addresses how successful companies often lose their mission and co…
How Sendbird became an AI-first company | John Kim (co-founder and CEO)
In this episode, Claire Vo interviews John Kim, co-founder and CEO of Sendbird, about their journey to becoming an AI-first company. They discuss Sendbird's in…
⚡️ Matt Pocock - Why Engineering Fundamentals matter MORE now
This episode features Matt Pocock discussing the enduring relevance of engineering fundamentals in the AI era, challenging the notion that AI negates the need…
Why cultivating agency matters more than cultivating skills in the AI era | Max Schoening (Notion)
In this episode, Lenny Rachitsky and Max Schoening discuss the profound impact of AI on product development, emphasizing that 'agency' is more crucial than tra…
Baseten CEO Tuhin Srivastava on Custom Models, and Building the Inference Cloud
Tuhin Srivastava, CEO of Baseten, discusses the explosive growth of the AI inference market, predicting over $1 billion in revenue for his company this year. H…
The $15B Physical AI Company: Simulation, Autonomy OS, Neural Sim, & 1K Engineers—Applied Intuition
This episode features Peter Ludwig and Qasar Younis, co-founders of Applied Intuition, a $15B company building "physical AI" for autonomous machines across var…
How a non-technical founder built a $100K ARR meme company | Jason Levin (Memelord CEO)
In this unhinged episode, Jason Levin, founder and CEO of Memelord, shares his journey as a non-technical founder building a meme company to $100K ARR using no…
⚡️ Competing with ChatGPT and Sierra, building a $10M ARR company — Yasser Elsaid, Founder, Chatbase
Yasser Elsaid, founder of Chatbase, discusses his journey from a bootstrapped side project to a $10M ARR AI customer service company. He shares insights into C…
How to build a defensible company in the AI era | Evan Spiegel (Snapchat CEO)
Lenny Rachitsky interviews Evan Spiegel, CEO and co-founder of Snap, exploring the challenges of building durable consumer social products in the current tech…
How Anthropic’s product team moves faster than anyone else | Cat Wu (Head of Product, Claude Code)
Cat Wu, Head of Product for Claude Code at Anthropic, discusses the incredibly fast pace of product development in AI, the evolving role of Product Managers, a…