Issue No. 28Sunday, July 12, 2026250 episodes · 1007 articles
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Business20VC with Harry Stebbings

Now is the Time for the App Layer | OpenAI & Anthropic Won't Win the App Layer | Mike Mignano, USV

With Harry Stebbings, Mike Mignano · Sunday, July 12, 2026

Harry Stebbings speaks with Mike Mignano, a new General Partner at USV, about the evolving landscape of AI. They discuss USV's thesis-driven investment approach, focusing on the application layer of AI and "obliterating" existing markets rather than just automating. Mike shares his predictions for AI model development, the implications of always-on AI agents, and the importance of human alignment, while Harry challenges views on user privacy. The conversation also covers venture capital strategies, the economics of AI token spend, the rise of independent media, and key lessons for founders and VCs.