Issue No. 19Week ending Sunday, May 10, 2026540 episodes · 2385 articles
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🔬How GPT‑5 derived new results in theoretical physics and quantum gravity — Alex Lupsasca, OpenAI

With Brandon, RJ Honicky, Alex Lupsasca · Sunday, May 10, 2026

Alex Lupsasca from OpenAI discusses how GPT models have achieved superhuman capabilities in theoretical physics, detailing two groundbreaking papers on gluon and graviton scattering amplitudes where AI solved problems that stumped human experts. He explores the transformative impact of AI on research methodologies and the future of scientific publishing, while also addressing questions of AI's creativity and its role in scientific discovery.

Key takeaways

  • Alex Lupsasca from OpenAI reveals AI, once primarily a "super competent physicist" for calculations, is rapidly gaining the capacity to define novel research questions, matching human experts. Read more →
  • Traditional scientific papers are an inefficient relic, especially for complex knowledge like theoretical physics, says Alex Lupsasca from OpenAI. Read more →
  • OpenAI's GPT models resolved a physics puzzle that stumped human experts for over a year: defining single-minus gluon tree amplitudes. These specific interactions were long assumed to be impossible. Read more →
  • Alex Lupsasca, a researcher at OpenAI, initially doubted AI's ability to tackle complex scientific problems, believing it was limited to simple tasks like email. Read more →
  • AI 'Crushes' Foundational Problems: OpenAI's Alex Lupsasca notes that AI models can solve problems traditionally given to physics grad students to build confidence. This forces a rethinking of how the next generation truly learns and builds expertise when the "easy stuff" is automated. Read more →

5 articles from this episode

OpenAI: AI Now Asks The Right Research Questions

OpenAI's Alex Lupsasca reveals how AI, once seen as a calculator, now matches human experts in identifying critical follow-up questions for cutting-edge research. Implications for builders.

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