Issue No. 39Week ending Sunday, September 27, 2026485 episodes · 2075 articles
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Andreessen Horowitz Launches Horowitz Andreessen, New Models, Human Powered Agents, McLaren Rebrand

With John Coogan, Jordi Hays, Tyler Cosgrove, Ben Thompson, Gagan Biyani, Alex Ratner, Peter, Daniel · Sunday, September 27, 2026

John Coogan and Jordi Hays analyze Harvey's negative gross margin turnaround and Meta's testing of human concierges for its Muse AI agent. Stratechery's Ben Thompson joins to discuss why Amazon holds the ultimate moat against agentic e-commerce and how custom internal bots transform personal productivity. The episode also features interviews with Gagan Biyani on the launch of Horowitz Andreessen Academy, Alex Ratner on Snorkel AI's $350 million valuation round, and Swarm Aero CEO Peter on autonomous defense drones.

Key takeaways

  • Snorkel AI closed a new $350 million valuation round based on a clear thesis: raw data volume no longer improves frontier AI models. Read more →
  • Off-the-shelf software leaves micro-gaps; custom AI bots succeed by filling narrow "software-shaped holes" that commercial products ignore. Read more →
  • An Effective Altruist writing as Bentham's bulldog went viral for arguing insect welfare outweighs total human welfare in the aggregate. Read more →
  • Gagan Biyani raised $42 million to launch Horowitz Andreessen Academy, an in-person school based in San Francisco with Marc Andreessen and Eric Schmidt on the board. Read more →
  • Legal tech startup Harvey watched gross margins drop from positive 50% to negative 50% in June after customer token usage jumped 20-fold. Read more →
  • Bloomberg reported Meta uses human contractors to handle phone calls for its Muse assistant, turning edge cases into training data. Read more →

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