Issue No. 33Week ending Sunday, August 16, 2026539 episodes · 2379 articles
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BusinessMy First Million

3 killer businesses hiding in plain sight

With Sam Parr, Shaan Puri · Sunday, August 16, 2026

Sam Parr and Shaan Puri explore several pathways to entrepreneurial success, from uncovering the hidden, multi-billion dollar niche of monkey lab testing for pharmaceuticals to a philosophy of identifying and capitalizing on overlooked business opportunities. They break down Paul Graham's framework for doing great work, and discuss how to find one's lifelong obsession by revisiting childhood passions, concluding with an appreciation for San Francisco's unique culture of awe and quirky, experimental entrepreneurship.

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Key takeaways

  • Forget what your LinkedIn feed tells you. The most profitable ventures often hide in non-glamorous sectors like industrial generator servicing or blue dye manufacturing, ignored by most 'smart people.' Read more →
  • More than 20% of all drugs, from everyday pills to vaccines, are tested on monkeys because they are the closest biological proxy to humans before trials. It's a non-negotiable step in pharma. Read more →
  • To find original opportunities, let genuine excitement and interest act as your 'motor and rudder,' steering you away from crowded, competitive fields. Read more →

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