10+ hours of podcasts, in 5 minutes.
10 quotes from 1 episode on Huberman Lab, each with a timestamped link to the source.
Nolan Williams states that rapid brain stimulation treatments restore cognitive function and the capacity to learn. After a 5-day magnetic stimulation protocol, previously depressed patients regain the focus to read and understand therapy books.
A single or a few MDMA sessions provide significant anti-PTSD effects that sit well outside standard clinical expectations.
“MDMA appears to in one to a few MDMA sessions have an anti-PTSD effect that seems to be you know outside of the kind of standard assumed levels of PTSD improvement…”
From Psilocybin Shows Mental Health Is About Rewiring Brain Connections
Psilocybin treatments generate an overall decrease in brain activity.
“…overall decrease in the level of activity in the brain.”
From Psilocybin Shows Mental Health Is About Rewiring Brain Connections
Patients report experiencing spontaneous, mindful present moments after completing magnetic brain stimulation.
“…going to the beach and they're like totally having a what people describe as a pretty mindful present moment sort of experience.”
The prefrontal cortex acts as a central governor. When depression sets in, deeper emotional regions take over and direct the prefrontal cortex instead.
“…the sense of control kind of governor of the brain.”
“In depression, the deeper regions govern the prefrontal cortex…”
Applying magnetic stimulation to the prefrontal cortex distributes a regulating effect downward into the anterior cingulate, insula, and amygdala.
“If you do that in the actual scanner…”
“…you can see that that distributes down into the anterior singulate in the insula and the amydala.”
Following a rapid 5-day magnetic stimulation protocol, patients regain cognitive abilities. People report finally being able to study and comprehend therapy concepts.
“As soon as we get them well with the TMS approaches, you know, kind of rapid, 5-day approach…”
“…the next week we come in and see them and they'll say, you know what I did all weekend is I looked at my therapy books and now I can understand it.”
Both therapies achieve antidepressant effects by altering the specific connection between the subgenual anterior cingulate and the default mode network.
“…anti-depressant effects of psilocybin have a particular um connectivity change that we also see with our our TMS approaches, right? And it's this connectivity between the subgenial anterior singulate and the default mode network.”
From Psilocybin Shows Mental Health Is About Rewiring Brain Connections
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