Biohub: The Future of Biology is Open-Source with Mark Zuckerberg, Priscilla Chan, and Alex Rives

With Sarah Guo, Elad Gil, Mark Zuckerberg, Priscilla Chan, Alex Rives · Sunday, June 14, 2026

Mark Zuckerberg, Priscilla Chan, and Alex Rives discuss Biohub's mission to accelerate scientific progress through open-source tools and frontier AI combined with frontier biology. They delve into breakthroughs like ESM fold for protein design, the advantages of their non-profit model for broad impact, and their vision for personalized medicine by understanding biological systems hierarchically.

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Key takeaways

Biohub began with an audacious goal from Mark Zuckerberg: to "cure, prevent and manage all disease by the end of the century," a vision Priscilla Chan admits was met with laughter by Nobel-winning scientists. Read more →
For breakthroughs in complex fields like frontier biology, a non-profit structure can achieve "bigger impact" by getting tools into more scientists' hands faster than a for-profit model. Read more →

2 articles from this episode

Zuckerberg's Biohub: Cure Disease By Modeling Biology Hierarchically

Mark Zuckerberg and Priscilla Chan detail Biohub's strategy: couple frontier AI with biology to build models, starting with proteins. Learn their hierarchical approach.

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Zuckerberg: Why Biohub Went Non-Profit for Max Impact

Mark Zuckerberg and Priscilla Chan detail Biohub's non-profit, open-source model to accelerate scientific progress in frontier biology for broader, faster impact.